Scott A Weed Selected Research

Cortactin

1/2019	Cortactin Phosphorylation by Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function, and Tumor Cell Invasion.
5/2013	Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion.
3/2011	Revisiting the ERK/Src cortactin switch.
1/2011	Further insights into cortactin conformational regulation.
11/2010	Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.
9/2008	Cortactin branches out: roles in regulating protrusive actin dynamics.
1/2008	Actin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer.
9/2007	Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma.
8/2006	Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification.
8/2003	Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.

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Scott A Weed Research Topics

Disease

16	Neoplasms (Cancer) 01/2022 - 08/2006
6	Squamous Cell Carcinoma of Head and Neck 01/2022 - 08/2006
6	Neoplasm Metastasis (Metastasis) 05/2014 - 08/2003
4	Carcinoma (Carcinomatosis) 01/2014 - 08/2006
3	Lymphatic Metastasis 02/2011 - 08/2006
2	Breast Neoplasms (Breast Cancer) 05/2014 - 01/2014
2	Mouth Neoplasms (Oral Cancer) 01/2014 - 07/2011
1	Adenocarcinoma 01/2022
1	Wounds and Injuries (Trauma) 01/2019
1	Carcinoma in Situ 01/2014
1	Ovarian Neoplasms (Ovarian Cancer) 05/2013
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 11/2009
1	Adenoid Cystic Carcinoma (Cylindroma) 09/2007
1	Bacillary Dysentery (Shigellosis) 07/2004
1	Bacterial Infections (Bacterial Infection) 01/2004

Drug/Important Bio-Agent (IBA)

10	CortactinIBA 01/2019 - 08/2003
6	Proteins (Proteins, Gene)FDA Link 05/2014 - 08/2006
3	src-Family KinasesIBA 11/2010 - 07/2004
2	Matrix Metalloproteinases (MMPs)IBA 01/2022 - 01/2014
2	Actin-Related Protein 2-3 Complex (Arp2 3 Complex)IBA 01/2019 - 08/2006
2	Fibronectins (Fibronectin)IBA 01/2019 - 05/2013
2	Small Interfering RNA (siRNA)IBA 01/2019 - 08/2006
2	Biological ProductsIBA 05/2013 - 01/2013
2	Tyrosine (L-Tyrosine)FDA Link 11/2010 - 08/2006
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2022
1	Matrix Metalloproteinase InhibitorsIBA 01/2022
1	marimastatIBA 01/2022
1	andecaliximabIBA 01/2022
1	CollagenIBA 01/2022
1	TenascinIBA 01/2019
1	Casein Kinase II (Casein Kinase 2)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	silmitasertibIBA 01/2019
1	tubastatin AIBA 05/2014
1	Aurora Kinase AIBA 05/2014
1	MLN 8237IBA 05/2014
1	Peptide Hydrolases (Proteases)FDA Link 01/2014
1	4-Nitroquinoline-1-oxide (4 Nitroquinoline 1 oxide)IBA 01/2014
1	CarcinogensIBA 01/2014
1	SmokeIBA 10/2012
1	Nicotine FDA Link 10/2012
1	Actins (F Actin)IBA 03/2011
1	Biomarkers (Surrogate Marker)IBA 02/2011
1	Neuronal Wiskott-Aldrich Syndrome Protein (Wiskott Aldrich Syndrome Protein, Neuronal)IBA 11/2010
1	Phosphotransferases (Kinase)IBA 11/2010
1	Serine (L-Serine)FDA Link 11/2010
1	Microfilament Proteins (Actin Binding Proteins)IBA 11/2010
1	AntibodiesIBA 11/2010
1	Metalloproteases (Metalloproteinases)IBA 11/2009
1	matrigelIBA 11/2009
1	saracatinibIBA 11/2009
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2008
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2008
1	Cyclin D1IBA 09/2007
1	ErbB Receptors (EGF Receptor)IBA 08/2006
1	Gefitinib (Iressa)FDA Link 08/2006
1	Actin-Related Protein 2IBA 08/2006
1	F-actin-binding proteinsIBA 08/2006
1	AsparagineIBA 01/2004
1	Aspartic Acid (Aspartate)FDA Link 01/2004
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2003

Therapy/Procedure

3	Therapeutics 01/2019 - 11/2010